詳細(xì)內(nèi)容

產(chǎn)品名稱：Marein

產(chǎn)品編號(hào)：ZN41171

品牌：Yuanmu

規(guī)格：20mg

別名：3-異丙基-4-甲氧/基苯甲醛;馬里甙;馬里苷

英文名：Marein

CAS號(hào)：535-96-6

分子式：C21H22O11

分子量：450.4

Marein通過(guò)減少對(duì)線粒體功能的損害和AMPK信號(hào)通路的激活而具有神經(jīng)保護(hù)作用。Marein通過(guò)CaMKK/AMPK/GLUT1促進(jìn)葡萄糖攝取，通過(guò)IRS/Akt/GSK-3β增加糖原合成，并通過(guò)Akt/FoxO1減少糖異生，從而改善HepG2細(xì)胞中高葡萄糖誘導(dǎo)的胰島素抵抗。Marein是一種HDAC抑制劑，IC50為100µM。Marein具有有益的抗氧化，降壓，降血脂和抗糖尿病作用。

生物活性

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function ａnd activation of the AMPK signal pathway.Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake,through IRS/Akt/GSK-3βto increase glycogen synthesis,and through Akt/FoxO1 to decrease gluconeogenesis.Marein is a HDAC inhibitor with an IC50 of 100µM.Marein has beneficial antioxidative,antihypertensive,antihyperlipidemic ａnd antidiabetic effects

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原創(chuàng)作者：上海遠(yuǎn)慕生物科技有限公司

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